Early Immune Programming and the Allergy March: What Every Paediatrician Should Know

Early immune programming plays a pivotal role in shaping a child’s susceptibility to allergic diseases, which often follow a predictable sequence known as the allergy march. This progression typically begins with atopic dermatitis and food allergy in infancy, followed by asthma and allergic rhinitis in later childhood. Understanding how genetic predisposition, environmental exposures, diet, and microbial influences interact to shape immune tolerance is essential for paediatricians. Early recognition of risk factors, timely interventions, and preventive strategies can alter disease trajectories. By appreciating these mechanisms, clinicians can better counsel families, guide management, and potentially reduce the long-term burden of allergic disease.

Dr. Nirmal Jain

MBBS, MD - Paediatrics, Life Member of IAP, NNF, Senior Consultant Paediatrician, Associate with International Health Regulations

Speaker