Probiotics in Preterm Infants: Shaping the Gut and Metabolic Future

Probiotics play a crucial role in modulating gut microbiota and improving health outcomes in preterm infants, who are vulnerable to intestinal dysbiosis due to immature immunity and antibiotic exposure. Supplementation with specific strains, such as Lactobacillus and Bifidobacterium, has shown promise in reducing the incidence of necrotising enterocolitis (NEC), late-onset sepsis, and feeding intolerance. Emerging evidence suggests that early probiotic intervention may influence long-term metabolic programming by promoting gut barrier integrity and modulating systemic inflammation. While safety and strain-specific efficacy remain key considerations, probiotics represent a valuable adjunct in shaping the gut and metabolic future of preterm neonates.

Dr. Johnny Sebastian

MBBS, MD, DCH, Chairperson of PAAI & IAP, Consultant Paediatrician with the Health Service Department, Government of Kerala

Speaker